Increasing our understanding of biomolecular interactions through high resolution Atomic Force Microscopy 

 

My research interests lie in understanding how variations in DNA structure can affect fundamental biological processes such as replication and transcription. To that end I am motivated by determining biomolecular mechanisms of action, with a long-term view to improved development of therapeutics. My scientific achievements include the first observation of single-molecule variations in the double-helical structure of DNA. I have been awarded both MRC and EPSRC fellowships to investigate the effect of DNA structure and topology on DNA-protein binding interactions.  

 
 

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