Increasing our understanding of biomolecular interactions through high resolution Atomic Force Microscopy
My research interests lie in understanding how variations in DNA structure can affect fundamental biological processes such as replication and transcription. To that end I am motivated by determining biomolecular mechanisms of action, with a long-term view to improved development of therapeutics. My scientific achievements include the first observation of single-molecule variations in the Watson-Crick double-helix structure. I have been awarded both MRC and EPSRC fellowships to investigate the effect of DNA structure and topology on DNA-protein binding interactions. This work aims to improve our understanding of anti-cancer and antibacterial therapeutics and their targets towards an improved drug discovery pipeline.
The cover of the current issue of ACS Synthetic Biology highlights the our collaborative research project with UCL Chemistry and the National Physical Laboratory to engineer a programmable inside-out “virus”. This everted “virus” is designed to deliver functional proteins into live cells.
An E. coli bacterium with an outer membrane partially removed by the de-novo designed antimicrobial peptide Tilamin