Increasing our understanding of biomolecular interactions through high resolution Atomic Force Microscopy
My research interests lie in understanding how variations in DNA structure can affect fundamental biological processes such as replication and transcription. To that end I am motivated by determining biomolecular mechanisms of action, with a long-term view to improved development of therapeutics. My scientific achievements include the first observation of single-molecule variations in the Watson-Crick double-helix structure. I have been awarded both MRC and EPSRC fellowships to investigate the effect of DNA structure and topology on DNA-protein binding interactions. This work aims to improve our understanding of anti-cancer and antibacterial therapeutics and their targets towards an improved drug discovery pipeline.
New antibiotics are desperately needed: without them antimicrobial resistance is predicted to kill more people than cancer. An international collaboration between scientists at the London Centre for Nanotechnology (LCN), University of Oxford, IBM, STFC Daresbury Laboratory and the National Physical Laboratory (NPL) has shown that our own bodies may provide an answer.
Kavit Main has joined the group to carry out a research project for his MSc in Cancer at the UCL Cancer Institute. His project aims to use Atomic Force Microscopy to gain single-molecule insights into supercoiled DNA-topoisomerase interactions.
Aside from academia, Kavit practises Nasta’liq and Devanagari calligraphy, Mughal miniature painting and enjoys Urdu poetry and hiking.
The cover of the current issue of ACS Synthetic Biology highlights the our collaborative research project with UCL Chemistry and the National Physical Laboratory to engineer a programmable inside-out “virus”. This everted “virus” is designed to deliver functional proteins into live cells.
An E. coli bacterium with an outer membrane partially removed by the de-novo designed antimicrobial peptide Tilamin